A review on the molecular basis of stemness of mesenchymal stem cells

Mesenchymal stem cells (MSCs) are increasingly becoming the focal point of research in regenerative medicine due to their potential differentiate into several different lineages including those non-mesodermal origin. With reports successful differentiation MSCs cell types such as osteocytes, chondrocytes, cardiocytes and even fully functional neurons, it is more important than ever understand stemness these at a molecular level. While no gene has been identified that unique MSCs, there have speculations maintained similarly Embryonic Stem Cells (ESCs). This review takes look four genes, namely, NANOG, OCT4, SOX2 & KLF4, role maintaining MSCs. These genes significant for ESCs therefore, could play well.